To support our ratings, we developed an algorithm to grade quality of evidence using concrete rules. Within our overview, reviewers found that current GRADE guidance was insufficient to make reliable and consistent judgments. One recommended use of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach is supporting quality assessment of evidence of comparisons included within a Cochrane overview of reviews.
7 Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
6 Institute for Applied Health Research and the School of Health and Life Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow G4 0BA, UK.5 Wissenschaftliches Institut, Private Europäische Medizinische Akademie der Klinik Bavaria in Kreischa GmbH, An der Wolfsschlucht 1-2, 01731 Kreischa, Germany.4 Centre for Clinical Brain Sciences, Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh EH16 5NN, UK.
3 Academic Section of Geriatric Medicine, Level 2, New Lister Building, Glasgow Royal Infirmary, Glasgow G31 2ER, UK.Electronic address: 2 Nursing, Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Buchanan House, Cowcaddens Road, Glasgow G4 0BA, UK. 1 Nursing, Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Buchanan House, Cowcaddens Road, Glasgow G4 0BA, UK.